3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water.

3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) induces gene mutations and inhibits metabolic cooperation in cultured Chinese hamster cells.

Investigations were carried out on 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a potent direct-acting bacterial mutagen found in chlorinated tap water, for the potential to induce 6-thioguanine (6-TG) resistant mutations in cultured Chinese hamster V79 cells. The mutagenicity of MX was manifested when cells were treated with MX in Hanks balanced salt solution, but not in serum-fr...

DRAFT: Evidence on the carcinogenicity of MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone

Carcinogenicity of the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in the rat.

BACKGROUND Several epidemiologic studies have suggested that the consumption of chlorinated drinking water may be associated with the development of certain cancers in humans. 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a byproduct of the chemical reactions that occur in chlorinated drinking water, has been found to be mutagenic in bacteria and mammalian cells; however, its poten...

Comparative cytotoxic and genotoxic potential of 13 drinking water disinfection by-products using a microplate-based cytotoxicity assay and a developed SOS/umu assay Shao-hui Zhang1,2,3, Dong-yue Miao1,2, Li Tan1,2, Ai-lin Liu1,2,* and Wen-qing Lu1,2

The implications of disinfection by-products (DBPs) present in drinking water are of public health concern because of their potential mutagenic, carcinogenic and other toxic effects on humans. In this study, we selected 13 main DBPs found in drinking water to quantitatively analyse their cytotoxicity and genotoxicity using a microplate-based cytotoxicity assay and a developed SOS/umu assay in S...

Solid-Phase Microextraction for Determination of 3-Chloro-4-(dichloromethyl)- 5-hydroxy-2[5H]-furanone in Water

Microextração em fase sólida, usando a derivatização on-line com bis(trimetilsilil)trifluoroacetamida, cromatografia a gás e espectrometria de massas, foi avaliada para a quantificação de 3-cloro-4-(diclorometil)-5-hidróxi-2(5H)-furanona (MX) em amostras de água. Foram usadas fibras de diferentes polaridades empregando a amostragem por imersão e por headspace. Para o sistema de imersão, foram a...